Neolignans from Licaria chrysophylla and Licaria aurea with DNA topoisomerase II-α inhibitory activity
نویسندگان
چکیده
منابع مشابه
Antitumor quinolones with mammalian topoisomerase II mediated DNA cleavage activity.
Ninety quinolones were evaluated to determine whether their ability to induce mammalian topoisomerase II mediated DNA cleavage in vitro correlated with their antitumor activity in vivo. Ten quinolones generated linear DNA at a yield of more than 10% of substrate supercoiled DNA in the mammalian topoisomerase II mediated DNA cleavage assay. All of these compounds showed a significant increase in...
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BACKGROUND Calpurnia aurea is an African medicinal plant used in many countries in Africa to treat a range of medical conditions or disorders. Extracts of the plant were shown to be active in antibacterial and antioxidant assays as well as against lice, ticks and maggots. The aim of the study was to isolate the phytochemical constituents from the plant and to test them in appropriate bioassays ...
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Most DNA intercalators and epipodophyllotoxins inhibit mammalian topoisomerase II by trapping the enzyme within DNA cleavage complexes that can be detected in cells as protein-associated DNA strand breaks. We have characterized previously a line of Chinese hamster cells (DC3F/9-OHE cells) the resistance of which to the cytotoxic effect of intercalators and etoposide is associated with a reduced...
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referred to as "topoisomerase II poisons", trap the enzyme in an intermediate complex with DNAwhich prevents the final rejoining step of the reaction and results in increased DNAstrand breaks2). Nowit is generally accepted that the ability to form a cleavable complex with topoisomerase II is responsible for the antitumor activity of these drugs3). In order to identify a specific newtopoisomeras...
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DNAtopoisomerases are enzymes that alter DNA conformation through a concerted breaking and rejoining of DNAstrands thereby controlling the topological state of DNA1}. Topoisomerase II has been shown to be the primary cellular target for a numberof clinically important antitumor agents with diverse and unrelated chemical structures2'3*. These antitumor drugs, referred as to "topoisomerase II poi...
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ژورنال
عنوان ژورنال: Química Nova
سال: 2012
ISSN: 0100-4042
DOI: 10.1590/s0100-40422012001100024